Simvastatin
Therapeutic Category
HMG-CoA Reductase Inhibitor
Usage of simvastatin
Used with dietary therapy for the following:Secondary prevention of cardiovascular events in hypercholesterolemic patients with established coronary heart disease (CHD) or at high risk for CHD: To reduce cardiovascular morbidity (myocardial infarction, coronary revascularization procedures) and mortality; to reduce the risk of stroke and transient ischemic attacks
Hyperlipidemias: To reduce elevations in total cholesterol, LDL-C, apolipoprotein B, and triglycerides in patients with primary hypercholesterolemia (elevations of 1 or more components are present in Fredrickson type IIa, IIb, III, and IV hyperlipidemias); treatment of homozygous familial hypercholesterolemia
Heterozygous familial hypercholesterolemia (HeFH): In adolescent patients (10-17 years of age, females >1 year postmenarche) with HeFH having LDL-C ≥190 mg/dL or LDL ≥160 mg/dL with positive family history of premature cardiovascular disease (CVD), or 2 or more CVD risk factors in the adolescent patient
Side effects of Simvastatin:
Some additional Zocor warnings include:
- Do not use these medicines if you have liver disease
- Do not use these medicines if you are pregnant or nursing
- Use these medicines with caution if you are also taking Gemfibrozil, Amiodarone, Verapamil, or blood thinners (anticoagulants)
- People who use some HIV medicines, birth control pills (oral contraceptives), Nefazodone, and niacin should talk to their doctor about the specific risks of using statins
- Drinking large amounts of grapefruit juice every day may affect the medicine
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