Therapeutic Category

HMG-CoA Reductase Inhibitor

Usage of simvastatin

Used with dietary therapy for the following:
  Secondary prevention of cardiovascular events in hypercholesterolemic patients with established coronary heart disease (CHD) or at high risk for CHD: To reduce cardiovascular morbidity (myocardial infarction, coronary revascularization procedures) and mortality; to reduce the risk of stroke and transient ischemic attacks

  Hyperlipidemias: To reduce elevations in total cholesterol, LDL-C, apolipoprotein B, and triglycerides in patients with primary hypercholesterolemia (elevations of 1 or more components are present in Fredrickson type IIa, IIb, III, and IV hyperlipidemias); treatment of homozygous familial hypercholesterolemia

  Heterozygous familial hypercholesterolemia (HeFH): In adolescent patients (10-17 years of age, females >1 year postmenarche) with HeFH having LDL-C ≥190 mg/dL or LDL ≥160 mg/dL with positive family history of premature cardiovascular disease (CVD), or 2 or more CVD risk factors in the adolescent patient 

Side effects of Simvastatin: 

More serious Zocor side effects can include myopathy (muscle pain and tenderness), rhabdomyolysis (a breakdown of muscle cells), cardiomyopathy (a decrease in heart muscle function), and liver disease. Zocor or simvastatin side effects can also include gas, dizziness, constipation, headache, diarrhea, or upset stomach. 

Some additional Zocor warnings include:
  • Do not use these medicines if you have liver disease
  • Do not use these medicines if you are pregnant or nursing
  • Use these medicines with caution if you are also taking Gemfibrozil, Amiodarone, Verapamil, or blood thinners (anticoagulants)
  • People who use some HIV medicines, birth control pills (oral contraceptives), Nefazodone, and niacin should talk to their doctor about the specific risks of using statins
  • Drinking large amounts of grapefruit juice every day may affect the medicine
Consult your physician to discuss the full range of Zocor side effects. 

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